C
- Adrienne Camp, singer-songwriter
- Captain Stu, ska, funk, punk, and soul fusion band
- Cassette
- Tony Cedras (1952–), musician
- Yvonne Chaka Chaka, singer
- Chris Chameleon, solo artist, lead singer and bass guitarist for Boo
- Blondie Chaplin, singer and guitarist
- Chevy, jazz/blues group
- Johnny Clegg
- Clockwork Surrender, alternative rock band
- Clout, all-girl rock group
- Basil Coetzee, saxophonist
- Mimi Coertse, musician
- Corsette
- Tony Cox, guitarist
- Crashcarburn
- Crossingpoint, Christian progressive hardcore band
- Cutting Jade
- Civil Twilight (band)
Read more about this topic: List Of South African Musicians