U
- Underground by Mayfair Games
- Underworld by Synister Creative Systems Urban fantasy set in modern day New York.
- Unhallowed Metropolis by Eos Press
- Unisystem by Eden Studios, Inc.
- Universe - by SPI, SF adaptation of DragonQuest
- Unknown Armies
- URPG - a free and universal RPG Rules System
- Usagi Yojimbo - based on the comic book series, Usagi Yojimbo, by Stan Sakai
- USS Infinity - a new and different RPG
Read more about this topic: List Of Role-playing Games By Name