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- Saga A Swedish fantasy role-playing game.
- Savage Worlds
- The Sci-Fi Sagas - A Player's Guidebook for Ironwood Omnimedia Company's E-RPG System
- Scion: Hero Modern day children of the gods by White Wolf Publishing
- Sea Dracula (The role-playing game of lawyers in animal city) - Nick Smith and Jake Richmond
- Sengoku (role-playing game) by Gold Rush Games Historical fantasy set in feudal Japan.
- SenZar - a game notorious for its blatant encouragement of munchkinism.
- Septerra Core
- Serenity by Margaret Weis Productions, Ltd, based on the Firefly television series.
- Seventh Sea by Alderac Entertainment Company
- Shab-al-Hiri Roach by Bully Pulpit Games
- Shadowforce Archer by Alderac Entertainment Group - a setting for Spycraft
- Shadow Nations (Obsidian Europe Horror, Scifi, fantasy)
- Shadowrun (cyberpunk fantasy)
- Shard RPG (anthropomorphic heroic-fantasy)
- Shatterzone
- Shock: Social Science Fiction
- Silver Age Sentinels by Guardians of Order
- Simply Roleplaying! by Microtactix, a simple and customizable generic open gaming system similar to Fuzion and the Action! System
- Sine Requie - Italian horror role-playing game.
- Skull and Crossbones - Pirate Adventures on the Spanish Main by FGU
- Skyrealms of Jorune by SkyRealms Publishing, later Chessex
- SLA Industries by Nightfall Games
- Sorcerer by Ron Edwards
- Space 1889 by GDW - Victorian Era Sci-Fi (steampunk)
- Space Gothic - German crossover between military science fiction, space opera and horror.
- Space Opera by Fantasy Games Unlimited
- Spacemaster - the SF adaptation of Rolemaster
- SpaceNinjaCyberCrisis XDO by Crucible Design - a tongue-in-cheek anime game
- Spaceship Zero by Green Ronin Publishing
- Spirit of the Century by Evil Hat Productions - a pulp game using the FATE system
- Spycraft by Alderac Entertainment Group - espionage adventure
- Star Frontiers by TSR
- StarCraft Adeventure by TSR Inc.
- Star*Drive by TSR, Inc.
- Starfaring by Flying Buffalo
- Stargate SG-1 (RPG) by AEG
- Starhedge by Empire Wargames
- Star Riders by Ianus Games - parody of space opera
- Starship Troopers (RPG) by Mongoose Publishing
- Star Hero - the SF adaptation of Fantasy Hero's Hero System
- Star Traders - space opera RPG for the Android platform
- Star Trek
- Star Wars: The Roleplaying Game - the D6 System ancestor published by West End Games (1987-1999)
- Star Wars Roleplaying Game - the D20 System version published Wizards of the Coast (2000-2010)
- Star Wreck Roleplaying Game - a parody game based on the Star Wreck movie franchise, written by Mike Pohjola.
- SteamCraft by Perilous Journeys Publishing - Steampunk, Neo-Victorian
- Steampunk Bonanza! - a fast action roleplaying game, written by Figby McSpoons
- STOCS by Wasteland Games - modern-day generic system
- Stormbringer, by Chaosium, based on Michael Moorcock's Elric of Melniboné stories
- St. Palmer's a Pirate/West Indies RPG
- Superhero 2044
- Squawk - is about intelligent archosaurs in another star system, by the Game Arts Guild.
- Sundered Epoch: Generations - A multi-genre game system by Randal Snyder
- Super Crusaders by Lee Walser - modern-day super hero system
- Super Powers Unlimited by Super Powers Unlimited, LLC
- Super Squadron - an Australian Super-Hero game.
- Supernatural by Margaret Weis Productions, Ltd, based on the CW Supernatural television series.
- Superworld by Chaosium
- Swordbearer by Heritage Games and Fantasy Games Unlimited
- Swords & Wizardry by Mythmere Games. A free 'clone' of the original version of Dungeons & Dragons.
- Sword World RPG (Japanese)
- Synnibarr (aka The World Of Synnibarr) by Craig McCracken. Notorious for a nonsensical, poorly explained game-world and huge power-levels granted to beginning player characters.
- Systems Failure by Palladium Books
Read more about this topic: List Of Role-playing Games By Name