Miscellaneous
- Thurman Arnold (1891–1969), lawyer/judge; born in Laramie
- Edward L. Baker, Jr. (1865–1913), United States Army, Medal of Honor; born in Laramie County, Wyoming
- Harold Roe Bartle (1901–1974), lawyer; politician; helped to establish Scouting in Wyoming
- George T. Beck (1856–1943) politician; businessman; helped William Cody establish the town of Cody
- "Buffalo Bill" Cody (1846–1917), colorful Old West figure, helped create Cody
- John Colter (1774–1813), explorer, first white man to set foot in Wyoming
- James M. Flinchum (1916–2011), newspaperman
- Otto Franc (1846–1903), cattle baron and homesteader in the Big Horn Basin
- Lilian Heath, first female doctor in Wyoming
- James L. Herdt, Master Chief Petty Officer of the Navy; born in Casper
- Leonard S. Hobbs (1896–1977), aeronautical engineer and author, won 1952 Collier Trophy for designing the P&W J57 turbojet engine; born in Carbon County
- Ralph S. Johnson (1906–2010), aviation pioneer and former state legislator from Laramie County
- William T. Kane (1932–2008), physicist in field of fiber optics
- David "Tex" Little (1902–2006), World War I veteran
- Esther Hobart Morris (1814–1902), appointed first female judge in United States in 1870 to complete the term of a justice who resigned in protest of Wyoming Territory's passage of women's suffrage
- Harold McCracken (1894–1983), creator and director of the Buffalo Bill Historical Center in Cody
- M. Margaret McKeown (born 1951), US Appeals Court Judge; born in Casper, Wyoming
- Margaret Murie (1902–2003), conservationist; lived in Wyoming
- John Pedersen, prolific firearms designer who worked for Remington Arms
- Chance Phelps (1985–2004), soldier; born in Dubois
- Jedediah Smith (1799–1831), mountain man, trapper, explorer, first American to get to California from the East
- Matthew Shepard (1976–1998), murdered student from University of Wyoming; born in Casper
- Gerry Spence (born 1929), lawyer; born in Laramie
- Willis Van Devanter (1859–1941), city attorney for Cheyenne; chief judge of the Wyoming territorial court
- Robert R. Wilson (1914–2000), physicist who was a group leader of the Manhattan Project; born in Frontier
- This list is incomplete; you can help by expanding it.
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