Other
- Ramona Africa – only adult to survive the 1985 bombing of the MOVE house
- Gloria Allred – attorney
- Joellyn Auklandus - writer
- Sydney Biddle Barrows – illegal escort service proprietor, often referred to as "The Mayflower Madam"
- Guion Bluford – astronaut, first African-American in space
- Antuan Bronshtein – convicted murderer
- Pete Conrad – astronaut, third man to walk on the moon (Apollo 12)
- Katherine Drexel – Roman Catholic saint
- Ira Einhorn – Environmental/antiwar activist, convicted murderer
- Daniel Faulkner – Philadelphia police officer killed in the line of duty in 1981 by Mumia Abu-Jamal, who was convicted of his murder
- Christopher Ferguson – astronaut
- Jacquelyn Frazier-Lyde – Philadelphia Municipal Court judge, boxer, daughter of Joe Frazier
- Barbara Clementine Harris – first female bishop ordained in the Anglican Communion
- Paul B. Higginbotham – judge, Wisconsin Court of Appeals
- James Martin – Jesuit priest, writer (My Life with the Saints), and frequent media commentator on modern Catholicism
- Seamus McCaffrey – justice, Supreme Court of Pennsylvania; former presiding judge of the "Eagles Court"
- Carol McCain – ex-wife of presidential candidate John McCain
- Silas Weir Mitchell – physician, writer
- Bawa Muhaiyaddeen – Sufi saint
- John Joseph O'Connor – Roman Catholic cardinal; archbishop, Archdiocese of New York, 1984–2000
- Marjorie Rendell – judge, U.S. Court of Appeals for the Third Circuit, 1997–present; first lady of Pennsylvania, 2003–present
- Amber Rose – model
- Nicodemo Scarfo – mafioso; head of the Scarfo crime family, 1981–1991
- Samuel Gilbert Scott – daredevil
- Lester Shubin – Inventor of the Kevlar vest
- Nancy Spungen – girlfriend of Sex Pistols bassist Sid Vicious
- Walter E. Williams – economist and author
- Joshua Wurman – meteorologist, leader of VORTEX2.
Read more about this topic: List Of People From Philadelphia