Other
- Ernest Angley (born 1921), international Christian evangelist and pastor of Grace Cathedral (Akron, Ohio)
- Caleb Bradham (1866–1934), inventor of Pepsi-Cola (New Bern)
- Fred Brooks (born 1931), software engineer and computer scientist (Durham)
- Eliza Bryant (1827 – May 13, 1907), humanitarian
- Judy Clarke (born 1952), criminal defense attorney in many high-profile cases (Asheville)
- John Cocke (1925–2002), computer scientist (Charlotte)
- Chelsea Cooley (born 1983), Miss USA 2005 (Mint Hill)
- Virginia Dare (1587–1597?), first person of English heritage born in the New World, to the Roanoke Colony, "The Lost Colony" (Roanoke Island)
- Richard Jordan Gatling (1818–1903), inventor of the Gatling gun (Como)
- Billy Graham (born 1918), world-renowned evangelist and unofficial religious advisor to U.S. Presidents from Dwight D. Eisenhower to Bill Clinton (Charlotte)
- Jay U. Gunter (1911–1994), pathologist and amateur astronomer
- Kelly King (born 1948), Chairman and CEO of BB&T (Raleigh)
- Anne Graham Lotz (born 1948), Christian evangelist and daughter of Billy Graham (Montreat)
- Dan McGalliard (born 1940), (Burke County) inventor and innovator
- Benjamin Chavis Muhammad (born 1948), civil rights leader (Oxford)
- James Owens, former Chairman and CEO of Caterpillar Inc. (Elizabeth City)
- Erica Payne, public policy expert, commentator, author and strategist (Raleigh)
- Conrad Reed (1787–1845), found a large gold nugget while fishing, triggering the first gold rush in the United States (Midland)
- Afeni Shakur (born 1947), former Black Panther, philanthropist, and mother of Tupac Shakur (Lumberton)
- David A. Smith (born 1957), computer scientist, specializing in interactive 3D (Camp Lejeune)
- Thomas Sowell (born 1930), economist, social critic, political commentator, author (Gastonia)
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