Public Office
- Orland K. Armstrong (1893-1987), U.S. Representative, journalist and social activist.
- John Ashcroft (born 1942), governor of Missouri (1985–1993), U.S. Senator from Missouri (1995–2001), United States Attorney General (2001–2005).
- Thomas Hart Benton (1782–1858), U.S. Senator
- Roy Blunt, (born 1950), Seven-term U.S. Representative for Missouri's 7th congressional district. Former House Minority Whip. Current U.S. Senator
- Christopher S. "Kit" Bond (born 1939), former Missouri Governor, U.S. Senator from Missouri.
- Leonard Boswell (born 1934), U.S. Representative for Iowa's 3rd congressional district
- Bill Bradley (born 1943), former U.S. Senator for New Jersey, NBA Hall of Famer. Born and raised in Missouri
- Clarence Cannon (1879–1964), U.S. Congressional Representative 1923-1964, U.S. House Appropriations Committee Chairman
- Jean Carnahan, (born 1933), first Missouri woman to become a U.S. Senator, matriarch of the Carnahan political family
- Steven Chu, (born 1948), current U.S. Secretary of Energy
- John Danforth (born 1936), former U.S. Senator and United States Ambassador to the United Nations
- Thomas Eagleton (1929–2007), U.S. Senator from Missouri (1968–1987), 1972 Democratic Vice Presidential nominee
- David R. Francis, (1850–1927), U.S. Secretary of the Interior (1896–1897), U.S. Ambassador to Russia (1916–1917)
- J. William Fulbright (1905–1995), U.S. Senator, established the Fulbright Fellowships
- Dick Gephardt (born 1941), U.S. Representative from Missouri's 3rd congressional district (1977–2005); Democratic House Majority Leader (1989–1995); candidate for the Democratic nomination for president in the 2004 election
- Michael Gerson (born 1964), chief speechwriter for George W. Bush (2001–2006)
- Ulysses S. Grant, President of the United States (1869–1877)
- Michael Harrington (1928–1989), founder Democratic Socialists of America
- Alphonso Jackson (born 1945), 13th U.S. Secretary of Housing and Urban Development
- James Jones (born 1943), U.S. National Security Advisor under Barack Obama and retired USMC four-star general
- Jerry Litton, (1937–1976), two-term U.S. Representative and Democratic nominee for U.S. Senate in the 1976 election. Killed in a plane crash before the general election.
- Breckinridge Long (1881–1958), U.S. Ambassador to Italy and Assistant United States Secretary of State under President Franklin D. Roosevelt
- Claire McCaskill, State Auditor of Missouri (1999–2007); U.S. Senator (2007–present); first woman elected U.S. senator from Missouri
- James Benton Parsons (1911–1993), U.S. federal judge
- Nellie Tayloe Ross (1876–1977), governor of Wyoming (1925–1927); director of the United States Mint (1933–1953); first woman to serve as a state governor
- Ike Skelton, (born 1931), U.S. Congressman for the Missouri 4th District (1977–2011), Chairman U.S. House Armed Services Committee
- Stuart Symington, 1st Air Force Secretary and U.S. Senator from Missouri.
- Larry Thompson (born 1945), United States Deputy Attorney General under George W. Bush
- Harry S. Truman (1884–1972), President of the United States
- George Turner (1850–1932) U.S. Senator and International arbitrator
- David King Udall (1851–1938), served in Arizona Legislature, progenitor of the Udall political family
- Harold Volkmer (1931–2011), Twenty year member of the U.S. House of Representatives for northeast Missouri
- Jim Webb (born 1946), current U.S. Senator for Virginia and former United States Secretary of the Navy
- Pete Wilson (born 1933), 36th Governor of California, U.S. Senator (1983–1991)
Read more about this topic: List Of People From Missouri
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