C
- Darren Campbell - former sprinter representing Great Britain
- John Cassidy, an Irish-born sculptor and painter who lived in Manchester
- Sir Humphrey Chetham, merchant and benefactor of Chetham's Library, born in Crumpsall
- Richard Cobden (1804–1865): Sussex-born industrialist who moved to Manchester where he was politically active
- Roy Collins (1934-2009), cricketer who played for Lancashire and Cheshire, born in Clayton
- Peter Cundall OA, a horticulturist and television presenter born in Manchester
- Ian Curtis musician and singer in Joy Division
Read more about this topic: List Of People From Manchester