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- Umberto Saba (1883–1957), Italian author
- Vita Sackville-West (1892–1962), British author
- Marquis de Sade (1740–1814), French author, wrote The Hundred Twenty Days of Sodom
- Edgardo Sanabria Santaliz (b. 1951), Puerto Rican author
- Alberto Sandoval-Sánchez (b. 1954), Puerto Rican author
- George Santayana (1863–1952), Spanish-born American author and philosopher
- Silviano Santiago (b. 1936), Brazilian author, wrote Stella Manhattan (1985)
- Mayra Santos-Febres (b. 1966), Puerto Rican author, wrote Sirena Selena (2000)
- Sappho (ca 630? B.C.), Greek poet
- Severo Sarduy (1937–1993), Cuban author
- Frank Sargeson (1903–1982), New Zealander writer
- May Sarton (1912–1995), Belgian-born American author
- Dan Savage (b. 1964), writes advice column, Savage Love. His book Skipping Towards Gomorrah: The Seven Deadly Sins and the Pursuit of Happiness in America was published in 2002 by Dutton, and describes the author's experiences indulging in the seven deadly sins. The book was featured in The Best American Sex Writing 2004, and won a Lambda Literary Award.
- Sarah Schulman (b. 1958), American author and playwright
- Sarah Scott (1723–1795), English author
- Jess C Scott (b. 1986), Singaporean-born author, wrote New Order
- David Sedaris (b. 1956), American author, speaker, comedian.
- Shyam Selvadurai (b. 1965), Sri Lankan Canadian novelist, wrote Funny Boy (1994)
- Maurice Sendak (1928–2012), American author and illustrator, wrote Where the Wild Things Are (1963)
- Anna Seward (1742–1809), English poet.
- Ken Shakin (b. 1959), American writer
- Randy Shilts (1951–1994), American journalist, wrote The Mayor of Castro Street: The Life and Times of Harvey Milk (1982), And the Band Played on: Politics, People, and the AIDS Epidemic (1987)
- Ann Allen Shockley (b. 1927), African American author
- Edith Sitwell (1887–1964), English author
- Susan Sontag (1933–2004), American author, wrote AIDS and Its Metaphors (1989)
- Tom Spanbauer (b. 1946?), American author, wrote The Man Who Fell In Love With The Moon (1992)
- Sir Stephen Spender (1909–1995), English author
- Jack Spicer (1925–1965), American poet
- Gertrude Stein (1874–1946), American author, wrote The Autobiography of Alice B. Toklas (1933)
- Edward Irenaeus Prime-Stevenson (1868–1942), American author, wrote Imre (1906)
- Charles Warren Stoddard (1843–1909), American author
- Lytton Strachey (1880–1932), English author
- Susan Stryker, American transgender author, university professor, and filmmaker
- Howard Sturgis (1855–1920), Anglo-American author
- Algernon Swinburne (1837–1909), English poet
- John Addington Symonds (1840–1893), British author
Read more about this topic: List Of LGBT Writers