Italian Americans Who Were First in Their Field of Achievement
- Giuseppe Mario Bellanca, designer of the first monoplane in the United States with an enclosed cabin
- Frank Borzage, first person to win the Academy Award for Directing, for Seventh Heaven
- Enea Bossi, designer of the first stainless steel aircraft and designer of the disputed first fully human-powered plane
- Anthony Celebrezze (1910–1998), the first non-native to be appointed to the U.S. Cabinet
- Geraldine Ferraro, (born August 26, 1935), the first woman in U.S. history to be nominated for the Vice-Presidency of the United States from a major political party
- Ella T. Grasso (1919–1981), born Ella Rose Tambussi Grasso, first woman to be elected governor of a U.S. state without succeeding her husband
- Giuseppina Morlacchi (1846–1886), ballerina and dancer, who introduced the can-can to the American stage
- Nancy Pelosi, the first woman in U.S. history to hold the office of Speaker of the United States House of Representatives
- Dennis Tito, the world's first space tourist
- Joe Valachi (1904–1971), the first member of the Mafia to testify to the senate about organized crime
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