2000s
- Almost Famous (2000) -- One of the stops is Boston
- Death of a Salesman (2000)
- Me, Myself and Irene (2000)
- State and Main (2000)
- The Perfect Storm (2000) -- They sail from Gloucester, MA
- The Skulls (2000)
- The Weight of Water (2000) -- Set in New Hampshire
- What Lies Beneath (2000) -- Set in Vermont
- You Can Count of Me (2000) -- Early scene where he borrows money set in Worcester, MA
- Blow (2001) -- Starts in George Jung's hometown of Weymouth, MA
- Cabin Fever (2001)
- Harvard Man (2001)
- In the Bedroom (2001) -- Set in mid-coast Maine
- Legally Blonde (2001) -- Elle is a student at Harvard
- Riding in Cars with Boys (2001)
- Summer Catch (2001) -- Cape Cod, MA
- Super Troopers (2001)
- The Blue Diner (2001) -- Set in Boston
- The Heist (2001) -- A robbery at a small Boston airport
- The Weight of Water (2001)
- What's the Worst That Could Happen? (2001) -- Filmed (and presumably set) in Boston and elsewhere in MA
- Confessions of a Dangerous Mind (2002)
- Mister Deeds (2002)
- The Gray Man (2002)
- The Skulls II (2002)
- Alex & Emma (2003) -- Set in Boston
- Anger Management (2003) -- They drive to Boston to visit Buddy's mother
- Behind the Red Door (2003) -- Set in Boston
- Dreamcatcher (2003)
- Dumb and Dumberer: When Harry Met Lloyd (2003)
- Legally Blonde 2: Red, White & Blonde (2003)
- Mona Lisa Smile (2003)--Set at Wellesley College in Wellesley, Mass.
- Mystic River (2003) -- Set in Boston
- The Human Stain (2003)
- The Recruit (2003) -- James starts as a bartender in Boston
- The Skulls III (2003)
- X2 (2003) -- They visit Iceman's parents' home in Boston
- Irish Eyes (2004)
- Saint Ralph (2004)
- Spartan (2004)
- Still We Believe: The Boston Red Sox Movie (2004)
- The Stepford Wives (2004)
- Welcome to Mooseport (2004)
- Fever Pitch (2005)
- Ice Princess (2005) -- Harvard in Cambridge, MA
- The Family Stone (2005)
- War of the Worlds (2005) -- Ray tries to flee to Boston to meet his ex-wife
- Islander (2006) -- Set in Vinalhaven, ME
- Little Children (2006)
- The Departed (2006) -- Set in Boston
- The Legend of Lucy Keyes (2006)
- United 93 (2006)
- Vacationland (2006)
- Black Irish (2007)
- Dan in Real Life (2007) -- Set in Rhode Island
- Everybody Wants to Be Italian (2007) -- Set in Boston
- Gone Baby Gone (2007) -- Set in Boston
- The Game Plan (2007)
- The Great Debaters (2007) -- They travel to Harvard to debate in Cambridge, MA
- 21 (2008) -- MIT and Harvard Square in Cambridge, MA
- The Forbidden Kingdom (2008) -- Set in Boston
- "My Best Friend's Girl" (2008) -- Set in Boston
- The Women (2008) -- Connecticut
- Knowing (film) (2009) -- Set in Lexington, MA
- Surrogates (2009)
- Tell-Tale (2009)
- The Maiden Heist (2009)
- The Boondock Saints II: All Saints Day (2009)
- The Way We Get By (2009)
Read more about this topic: List Of Films Set In New England