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- Sancha of Aybar (1017–1070), Lady of Aybar
- Sancha of León (1037–1065), Queen of Leon
- Seondeok of Silla (632-647), Queen of Korea
- Sibilla of Cerdanya, Viscountess of Cerdanya, c1134-1141
- Sibylla of Jerusalem, Queen of Jerusalem
- Sibylle of Baux (1255–1294), also known as Simone of Bauge, Sibylle of Bauge, Lady of Baux, Bresse & Miribel, 1268-1293
- Sibylle of Baux, Lady of Baux, 1305–1348
- Sibylle of Burgundy (1152–1201), Countess of Chalon
- Sibylle of Chateaurenault, Lady of Chateaurenault, 1140-?
- Sibylle of Palau, Viscountess of Bas
- Sophie of Arnsberg and Rietberg, Heiress of the Lordship of Rheda
- Sophie of Bar, Countess of Bar, 1033–1092
- Stephanie of Ibelin, Lady of Nablus
- Stephanie of Milly (d.1197), Lady of Oultrejourdain
- Suzanne of Bourbon (1491–1521), Countess of Clermont-en-Beauvaisis, Forez, Gien, & La Marche, 1503–1521, Duchess of Auvergne & Bourbon, 1503–1521
Read more about this topic: List Of Female Rulers And Title Holders