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- Daisy Dalrymple is a journalist, married to a Detective Chief Inspector of Scotland Yard, in a historical mystery series commenced 1994 by Carola Dunn.
- Gloria Damasco is a Chicana private investigator in Los Angeles in a series commenced 1992 by Lucha Corpi.
- Jean and Louise Dana, The Dana Girls, are adventurous orphaned sisters living in a boarding school, in a series 1934-1979 by the Stratemeyer Syndicate most famous for creating the Nancy Drew mysteries.
- Kathryn Dance is an agent with the California Bureau of Investigation and an expert in body language, in Monterey, California, in two novels 2006 and 2007 by Jeffrey Deaver.
- Miss Abigail Danforth is determined to be a detective in a series set in the early 20th century by Marian J A Jackson.
- Jo Danville is a New York City police detective and former FBI Special Agent played by Sela Ward on the CBS series CSI:New York 2010 to present.
- Ziva David is a former agent of the Israeli Mossad and an agent of the Naval Criminal Investigative Service played by Cote de Pablo on the CBS series NCIS from 2005 to present.
- Charmian Daniels is a detective in a series of books by English crime novelist Jennie Melville (debuted 1962).
- Eve Dallas is a New York City police lieutenant in the 21st century in the ...in Death series of books by American novelist J. D. Robb (debuted 1995).
- Mrs Elizabeth Darcy (née Bennet) from Jane Austen’s Pride and Prejudice sleuths with her husband is a series by Carrie A. Bebris debuted 2004 with “Pride and Prescience".
- Elizabeth Darcy is a sleuth in the 2011 novel Death Comes to Pemberley by P. D. James.
- Phoebe Daring is a 16 year old who sets out to prove her twin brother Phil is innocent of bank fraud in The Daring Twins: A Story for Young Folk (1911) by L. Frank Baum and likewise defends another innocent man in Phoebe Daring (1912).
- Jane Da Silva is an expatriate lounge singer and widow who returns to Seattle after her uncle leaves her money on the condition that she solves hopeless cases, in a book series started 1993 by K. K. Beck who also wrote the Iris Cooper and Jack Clancy series.
- Dorcas Dean is a young lady detective who works with a private investigator to support her mother and husband in two series of short stories by George R Sims, 1897 and 1898.
- Hailey Dean is a prosecutor in the novel The Eleventh Victim by American television commentator Nancy Grace (debuted 2009).
- Kate Delafield is a lesbian LAPD homicide detective in an eight-book series by Katherine V. Forrest (debuted 1984).
- Evan Delaney is a lawyer turned freelance journalist in a series by Meg Gardiner commenced 2002 with "China Lake".
- Sarah Booth Delaney is a modern, impoverished, southern belle in a series by Carolyn Haines, commenced 1999 with Them Bones.
- Elena Delgado is an FBI agent played by Roselyn Sanchez on the CBS series Without a Trace from 2005 to 2009.
- Jade del Cameron, an American rancher's daughter who has served as an ambulance driver in WWI, is the protagonist of Suzanne Arruda's historical mystery series set in 1920s Africa.
- Sister Mary Teresa (Emtee) Dempsey detects in a series started 1981 by Ralph McInerney, author of the Father Dowling mysteries, writing as 'Monica Quill'.
- Claire De Witt is a pot smoking PI who uses dreams and omens to find the truth in New Orleans, in a 2011 book by Sara Gran, the start of a new series.
- Eve Diamond is an LA Times reporter in a book series commencing 2001 by Denise Hamilton.
- Laura Di Palma is a lawyer in a series by Lia Matera, debuted 1988.
- Maisie Dobbs is a private investigator in England in the period after WWI in a series by Jacqueline Winspear.
- Piper Donovan is a wedding caterer is a series by Mary Jane Clark.
- Jessie Drake is a divorced homicide detective appearing from 1993 in a series of novels by Rochelle Majer Krich.
- Nancy Drew is one of the best-known "girl detectives", starring in a multi-authored series of books created by Edward Stratemeyer (debuted 1930). Played in film by Bonita Granville in Nancy Drew – Detective (1938), Nancy Drew... Reporter (1939), Nancy Drew: Trouble Shooter (1939), and Nancy Drew and the Hidden Staircase (1939); by Pamela Sue Martin and Janet Louise Johnson on the ABC series The Hardy Boys/Nancy Drew Mysteries from 1977 to 1978; by Maggie Lawson in the 2002 television movie Nancy Drew; and by Emma Roberts in the 2007 film Nancy Drew.
- Margaret "Meg" Duncan is a mystery solving girl in The Meg Duncan books for children, published 1967-1972, written by "Holly Beth Walker" and illustrated by Cliff Shule.
- Daphne Du Maurier, the author, sleuths in a book series by Joanna Challis, commenced 2009.
- Sabrina "Bree" Duncan is a private detective played by Kate Jackson on the ABC series Charlie's Angels from 1976 to 1979.
- Olivia Dunham is an FBI agent played by Anna Torv on the 2008-present Fox series Fringe.
- Constance Dunlap is a reformed thief and detective in a series of short stories by American crime novelist Arthur B. Reeve (debuted 1913).
- Kannon Dupree is a time travelling detective ('timestalker') is a book series started 2009 by Australian Rhonda Roberts.
- Calleigh Duquesne is a crime scene investigator played by Emily Procter on the 2002-present CBS series CSI: Miami.
- Clarice Dyke is an early female detective, created in 1888 as the wife of an existing detective character, by 'Harry Rookwood'.
Read more about this topic: List Of Female Detective Characters