2010
| Date | Performer(s) | Mixes | Additional Notes |
| 18 December | No Performer(s) | BBC Radio 1 | Cancelled Deadmau5 Tour After Party in Glasgow |
| 11 December | Avicii | Mixes | |
| 4 December | Sander Kleinenberg | Mixes | |
| 27 November | Roska | Mixes | |
| 20 November | DJ 2000 and One | Mixes | |
| 13 November | Nero | Mixes | |
| 6 November | Wolfgang Gartner | Mixes | |
| 30 October | Magda | Mixes | |
| 23 October | Basement Jaxx | Mixes | |
| 16 October | Marcus Schossow | Mixes | |
| 9 October | Netsky | Mixes | |
| 2 October | Kim Fai | Mixes | |
| 25 September | Paul Woolford | Mixes | |
| 18 September | Doorly | Mixes | |
| 11 September | Joris Voorn | Mixes | Live from Creamfields 2010 |
| 4 September | Swedish House Mafia | Mixes | ESSENTIAL MIX OF THE YEAR - Live from Creamfields 2010 |
| 28 August | Danny Byrd | Mixes | |
| 21 August | The Count & Sinden | Mixes | |
| 14 August | Chris Lake | Mixes | |
| 8 August | Pete Tong, Japanese Popstars, Above & Beyond & Annie Mac | Mixes | Radio 1 in Ibiza Live from Privilege |
| 7 August | Sven Vath & Andre Galluzzi | Mixes | Radio 1 in Ibiza Live from Cocoon @ Amnesia |
| 6 August | Zane Lowe, Mark Ronson & Grandmaster Flash | Mixes | Radio 1 in Ibiza Live from Space |
| 31 July | Nick Curly | Mixes | |
| 24 July | Magnetic Man | Mixes | |
| 17 July | Pendulum | Mixes | |
| 10 July | Afrojack | Mixes | |
| 3 July | Justin Martin | Mixes | Dirtybird Records |
| 26 June | Annie Mac, Chase & Status, Rusko> replaced by Skream, Toddla T | Mixes | Extended 4 hour Essential Mix live from Glastonbury, UK |
| 19 June | Club 75 (Busy P, Cassius, DJ Mehdi, Justice), Boys Noize, Burns, Gary Beck | Mixes | Extended 4 hour Essential Mix live at Rockness, Scotland |
| 12 June | Chuckie | Mixes | |
| 5 June | Tim Green | Mixes | |
| 29 May | John Digweed | Mixes | |
| 22 May | Deadmau5, Mylo, Laurent Garnier | Mixes | Retrospective |
| 15 May | Boy 8 Bit | Mixes | |
| 8 May | Dave Spoon | Mixes | |
| 1 May | Breakage | Mixes | |
| 24 April | Aeroplane, Pete Tong, Sasha, Richie Hawtin | Mixes | 500th DJ Aeroplane |
| 17 April | Ferry Corsten | Mixes | |
| 10 April | Buraka Som Sistema | Mixes | |
| 3 April | James Zabiela | Mixes | |
| 27 March | Audio Bullys | Mixes | |
| 20 March | Sebastien Leger | Mixes | |
| 13 March | Noisia | Mixes | |
| 6 March | Kissy Sell Out, Alex Metric | Mixes | In New Music We Trust Live |
| 27 February | Faithless Sound System | Mixes | |
| 20 February | Jack Beats | Mixes | |
| 13 February | John '00' Fleming | Mixes | |
| 6 February | Riva Starr | Mixes | |
| 30 January | Annie Mac, Hostage | Mixes | Live from Sugarbeat in Edinburgh |
| 23 January | Four Tet | Mixes | |
| 16 January | Christian Smith | Mixes | |
| 9 January | Simian Mobile Disco | Mixes | |
| 2 January | Deadmau5, Justice, Eric Prydz, Plump DJs | Mixes | Ministry of Sound 2010 New Year's Eve party at the O2 Arena |
Read more about this topic: List Of Essential Mix Episodes