S
- Sade
- Saga
- Sailor
- Sameer Khan
- Sanctuary
- Sarai
- Joe Satriani
- Jill Scott (Hidden Beach/Epic)
- SCANDAL
- Scouting for Girls
- Screaming Trees
- The Script
- Sekar (UK)
- Selena Gomez & the Scene (Japan/UK/Ireland)
- Semi Precious Weapons
- Sepultura
- Serhat
- Shabba Ranks
- Shakin' Stevens
- Shakira
- The Shamen
- Shark Island
- Vonda Shepard (550 Music/Epic)
- Sherbet
- The Shooters (Epic Nashville)
- Pauly Shore (WTG/Epic)
- Shudder to Think
- Shut up Stella
- Silk 'n Sand
- Silverchair
- Juliet Simms
- Carly Simon
- The Sinceros
- Sister Souljah
- Skank
- Skunk Anansie
- Sly and the Family Stone
- Russell Smith (Epic Nashville)
- Social Distortion
- Sons of the Desert (Epic Nashville)
- Southside Johnny & The Asbury Jukes
- Sounds Under Radio
- Spin Doctors
- Starcastle
- Keith Stegall (Epic Nashville)
- Jim Steinman
- Tate Stevens (The X Factor USA contestant)
- Al Stewart
- The Stranglers
- Suede
- Suicidal Tendencies
- Donna Summer
- Henry Lee Summer
- Super Furry Animals
- Super Lover Cee & Casanova Rud
- Swiss Lips
Read more about this topic: List Of Epic Records Artists