List of Chemotherapeutic Agents - Comprehensive Table

Comprehensive Table

Intracellular chemotherapeutic agents / antineoplastic agents (L01)
SPs/MIs
(M phase)
Block microtubule assembly
  • Vinca alkaloids (Vinblastine#
  • Vincristine#
  • Vinflunine§
  • Vindesine
  • Vinorelbine)
Block microtubule disassembly
  • Taxanes (Cabazitaxel
  • Docetaxel#
  • Larotaxel
  • Ortataxel†
  • Paclitaxel#
  • Tesetaxel)
  • Epothilones (Ixabepilone)
DNA replication
inhibitor
DNA precursors/
antimetabolites
(S phase)
Folic acid
  • Dihydrofolate reductase inhibitor (Aminopterin
  • Methotrexate#
  • Pemetrexed
  • Pralatrexate)
  • Thymidylate synthase inhibitor (Raltitrexed
  • Pemetrexed)
Purine
  • Adenosine deaminase inhibitor (Pentostatin)
  • Halogenated/ribonucleotide reductase inhibitors (Cladribine
  • Clofarabine
  • Fludarabine)
  • Nelarabine
  • Thiopurine (Thioguanine#
  • Mercaptopurine#)
Pyrimidine
  • Thymidylate synthase inhibitor (Fluorouracil#
  • Capecitabine
  • Tegafur
  • Carmofur
  • Floxuridine)
  • DNA polymerase inhibitor (Cytarabine#)
  • Ribonucleotide reductase inhibitor (Gemcitabine)
  • Hypomethylating agent (Azacitidine
  • Decitabine)
Deoxyribonucleotide
  • Ribonucleotide reductase inhibitor (Hydroxycarbamide)
Topoisomerase inhibitors
(S phase)
I
  • Camptotheca (Camptothecin
  • Topotecan
  • Irinotecan
  • Rubitecan‡
  • Belotecan)
II
  • Podophyllum (Etoposide#
  • Teniposide)
II+Intercalation
  • Anthracyclines (Aclarubicin
  • Daunorubicin#
  • Doxorubicin#
  • Epirubicin
  • Idarubicin
  • Amrubicin†
  • Pirarubicin
  • Valrubicin
  • Zorubicin)
  • Anthracenediones (Mitoxantrone
  • Pixantrone)
Crosslinking of DNA
(CCNS)
Alkylating
  • Nitrogen mustards: Mechlorethamine
  • Cyclophosphamide# (Ifosfamide
  • Trofosfamide)
  • Chlorambucil# (Melphalan
  • Prednimustine)
  • Bendamustine
  • Uramustine
  • Estramustine
  • Nitrosoureas: Carmustine
  • Lomustine (Semustine)
  • Fotemustine
  • Nimustine
  • Ranimustine
  • Streptozocin
  • Alkyl sulfonates: Busulfan (Mannosulfan
  • Treosulfan)
  • Aziridines: Carboquone
  • ThioTEPA
  • Triaziquone
  • Triethylenemelamine
Platinum-based
  • Carboplatin
  • Cisplatin
  • Nedaplatin
  • Oxaliplatin
  • Satraplatin
Nonclassical
  • Hydrazines (Procarbazine#)
  • Triazenes (Dacarbazine#
  • Temozolomide)
  • Altretamine
  • Mitobronitol
  • Pipobroman
Intercalation
  • Streptomyces (Actinomycin#
  • Bleomycin#
  • Mitomycin
  • Plicamycin)
Photosensitizers/PDT
  • Aminolevulinic acid / Methyl aminolevulinate
  • Efaproxiral
  • Porphyrin derivatives (Porfimer sodium
  • Talaporfin
  • Temoporfin
  • Verteporfin)
Other
Enzyme inhibitors
  • FI (Tipifarnib)
  • CDK inhibitors (Alvocidib†
  • Seliciclib†)
  • PrI (Bortezomib
  • Carfilzomib)
  • PhI (Anagrelide)
  • IMPDI (Tiazofurin§)
  • LI (Masoprocol)
  • PARP inhibitor (Olaparib§)
  • HDAC (Panobinostat
  • Vorinostat
  • Romidepsin)
Receptor antagonists
  • ERA (Atrasentan)
  • Retinoid X receptor (Bexarotene)
  • Sex steroid (Testolactone)
Other/ungrouped
  • Amsacrine
  • Trabectedin
  • Retinoids (Alitretinoin
  • Tretinoin)
  • Arsenic trioxide
  • Asparagine depleters (Asparaginase#/Pegaspargase)
  • Celecoxib
  • Demecolcine
  • Elesclomol§
  • Elsamitrucin
  • Etoglucid
  • Lonidamine
  • Lucanthone
  • Mitoguazone
  • Mitotane
  • Oblimersen†
  • Omacetaxine mepesuccinate
  • Eribulin
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: NEO

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drug (L1i/1e/V03)

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