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- Fred Saberhagen: The Holmes-Dracula File (1978) and Seance for a Vampire (1994)
- Autumn Sabol : Elementary, My Dear (2004)
- Robert Saffron: The Demon Device a novel by Robert Saffron " as communicated " by Sir Arthur Conan Doyle (sic) a humorous pastiche
- Andrew Salmon: "The Adventure of the Locked Room" story in Sherlock Holmes Consulting Detective Volume One anthology (Cornerstone Book Publishers, June 2009)
- Siyaram Saran: The Boer War Mystery. Sherlock Holmes and Dr.Watson meet Sir Arthur Conan Doyle, who was there as a Medical Doctor and an Indian Barrister M.K.Gandhi (Mahatma Gandhi) in South Africa, who was then practising law there and who inspired Holmes to take up Bee-Keeping after his retirement.
- Dorothy L. Sayers
- Bernard J. Schaffer: Whitechapel: the Final Stand of Sherlock Holmes (16 June 2011)
- Christopher Sequeira: "His Last Arrow" in Gaslight Grimoire; "The Adventure of the Haunted Showman" and "The Return of the Sussex Vampire" in The Game's Afoot! (ed: David Stuart Davies).
- Stanley Shaw: "Sherlock Holmes at the 1902 Fifth Test" Sherlock Holmes discovering cricket
- Jay Sheckley : "Vittoria the Circus Belle", Confidential Casebook of Sherlock Holmes which Publishers Weekly called "The best of an excellent collection". Editor: Marvin Kaye
- Timothy Francis Sheil: The Siam Question ISBN 978-0-9538160-0-2 (Camden House Publishing Ltd, 1999)
- Sam Siciliano: The Angel of the Opera: Sherlock Holmes meets the Phantom of the Opera
- Aaron Smith: short story "The Massachusetts Affair" in Sherlock Holmes Consulting Detective Volume One (Cornerstone Book Publishers, 2009)
- D. O. Smith: "The Adventure of the Purple Hand" in The Further Adventures of Sherlock Holmes, 1985.
- Jô Soares: Xangô de Baker Street - a Sherlock Holmes in travel to Brazil meets Jack the Ripper, before the murders in Whitechapel.
- Vincent Starrett: novels and short stories "The Adventure of the Unique Hamlet" in The Further Adventures of Sherlock Holmes(1985), The Private Life of Sherlock Holmes
- Daniel Stashower: The Adventures of Ectoplasmic Man - where Holmes meets Houdini - as Editor ( with M H Greenberg & J L Lellenberg ) : Sherlock Holmes in America and Ghosts of Baker Street
- James R Stefanie: "The Charters Affair"
- Lauren Steinhauer: Sherlock Holmes' Lost Adventure : the True Story of the Giant Rats of Sumatra
- Julian Symons: "The Adventure of Hillerman Hall" in The Further Adventures of Sherlock Holmes, 1985
- Tim Symonds: Sherlock Holmes And The Dead Boer At Scotney Castle (MX Publishing 2012). Sherlock Holmes And the Case Of the Bulgarian Codex MX Publishing November 2012.
Read more about this topic: List Of Authors Of New Sherlock Holmes Stories