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- O'Fallon, Missouri – John O. Fallon
- O'Neals, California – Charles O'Neal (merchant and first postmaster)
- Ockenden, California – Thomas J. Ockenden (first postmaster)
- Odem, Texas – David Odem (San Patricio County sheriff)
- Odenton, Maryland – Oden Bowie (Governor of Maryland)
- Ogden, Utah – Peter Skene Ogden
- Ogilby, California – E.R. Ogilby (mine promoter)
- Old Ornbaun Hot Springs, California – John S. Ornbaun (early settler and rancher)
- Olean, New York – Olean Shephard (the first white child born here)
- Oleander, California – William Oleander Johnson (first postmaster)
- Orange, 4 places in Connecticut/Massachusetts/New Jersey/Virginia – William, Prince of Orange
- Orange, Ohio – William, Prince of Orange (indirectly, via Orange, Connecticut)
- Ordbend, California – Edward Ord
- Orem, Utah – Walter C. Orem (President of the Salt Lake and Utah Electric Urban Railroad)
- Orford, New Hampshire – Robert Walpole, Earl of Orford
- Orinda, California – Katherine Philips (a poet whose nickname was "Matchless Orinda")
- Orlando, Florida – Orlando Reeves
- Orleans, Massachusetts – Louis Philippe II, Duke of Orléans
- Orloff, California – Orloff Miller (early settler)
- Ornbaun, California – John S. Ornbaumn (early settler and rancher)
- Orono, Maine – Chief Joseph Orono of the Penobscot Nation
- Orrs Springs, California – Samuel Orr (early settler)
- Orwood, California – Orville Y. Woodward (promoter)
- Osburn, Idaho – Bill Osborne (trading post establisher) (note spelling)
- Osceola County, Florida – Indian leader Osceola, whose name means "Black Drink Cry"
- Otis, Massachusetts – Harrison Gray Otis
- Otisfield, Maine – James Otis, Jr. (grantee)
- Ovid, Colorado – Newton Ovid (local resident)
- Owensboro, Kentucky – Abraham Owen
- Oxnard, California – Henry, Ben, James and Robert Oxnard
Read more about this topic: List Of American Places Named After People