S
- Santa Fe Mysteries: Sacred Ground (1997) DOS, Mac, Win
- Santa Fe Mysteries: The Elk Moon Murder (1996) DOS, Mac, Win
- Sargon 5: World Class Chess (1991) DOS
- The Sci-Fi Collection (1995) DOS, Mac
- S.D.I. (1988) C64
- SDI: Strategic Defense Initiative (1987) Ami, ST, C64, ZX
- Seaquest (1983) ATR26
- Seastalker (1986) CPC
- Secret Weapons Over Normandy (2003) PS2, Win
- Shanghai (1986) Ami, CPC, AppII, ATR, ST, C64, DOS, Lynx, Mac, MSX, SMS, TRSCC
- Shanghai: Dynasty (1997) Mac, Win
- Shanghai: Great Moments (1995) Win
- Shanghai II: Dragon's Eye (1989) DOS, Genesis, MSX, SNES, Win
- Shanghai: Mah-Jongg Essentials (1999) Mac, Win
- Shanghai: Second Dynasty (1999) Mac, Win
- Shanghai: Triple-Threat (1994) 3DO, Sat
- Shaun Palmer's Pro Snowboarder (2001) PS2, GBA
- Shrek 2 (2004) GCN, PS2, Win, Xbox
- Shrek 2: Beg for Mercy! (2004) GBA
- Shrek 2 Team Action (2004) Win
- Shrek Smash n' Crash Racing (2006) GCN, PS2, PSP
- Shrek SuperSlam (2005) GBA, GCN, NDS, PS2, Win, Xbox
- Shrek the Third (2007) PS2, PSP, Wii, Win, X360
- Shrek: Forever After (2010) PS3, X360, Wii, DS
- Sid Meier's Civilization II (1998) PS1
- Singularity (2010) PS3, X360, PC
- The Simpsons Wrestling (2001) PS1
- SiN (1998) Win
- SiN: Wages of Sin (1999) Win
- Skate Boardin' (1987) ATR26
- Skiing (1980) ATR26
- Sky Jinks (1982) ATR26
- Sky Odyssey (2000) PS2
- Skylanders: Giants (2012) Wii, WiiU, 3DS, PS3, X360, Win, Mac
- Skylanders: Spyro's Adventure (2011) Wii, 3DS, PS3, X360, PC, Mac
- Soldier of Fortune (2000) Win
- Soldier of Fortune II: Double Helix (2002) Win, Xbox
- Sonic Boom (1990) Ami, CPC, ST, C64, ZX
- Space Invaders (1999) GBA, GBC, N64, PS1, Win
- Space Shuttle: A Journey into Space (1983) CPC, ATR26, Atari 5200, ATR, C64, MSX, ZX
- Spider Fighter (1982) ATR26
- Spider-Man (2000) DC, GBC, N64, PS1, Win
- Spider-Man 2 (2004) Win, NDS, GCN, PS2, PSP, Xbox
- Spider-Man 2: Enter Electro (2001) PS1
- Spider-Man 2: The Sinister Six (2001) GBC
- Spider-Man 3 (2007) GBA, Win, NDS, PS2, PS3, PSP, Wii, X360
- Spider-Man: Battle for New York (2004) GBA, NDS
- Spider-Man: Friend or Foe (2007) NDS, PC, PS2, PSP, X360, Wii,
- Spider-Man: Mysterio's Menace (2001) GBA
- Spider-Man: Shattered Dimensions (2010) PS3, X360, Wii, DS, Win
- Spider-Man: The Movie (2002) GBA, GCN, PS2, Win, Xbox
- Spider-Man: Edge of Time (2011) PS3, Wii, 3DS, X360
- Spindizzy (1986) AppII
- Spycraft: The Great Game (1996) DOS, Mac, Win
- Stampede (1981) ATR26, Intellivision
- Starmaster (1982) ATR26
- Star Rank Boxing (1985) CPC, C64, ZX
- Star Rank Boxing II (1987) AppII, C64, DOS
- Star Trek Action Pack (2002) Win
- Star Trek: Armada (2000) Win
- Star Trek: Armada II (2001) Win
- Star Trek: Away Team (2001) Win
- Star Trek: Bridge Commander (2002) Win
- Star Trek: ConQuest Online (2000) Win
- Star Trek: Elite Force II (2003) Win
- Star Trek: Hidden Evil (1999) Win
- Star Trek: Invasion (2000) PS1
- Star Trek: Starfleet Command III (2002) Win
- Star Trek: Voyager – Elite Force (2000) Win
- Star Wars: Bounty Hunter (2002) PS2
- Star Wars Jedi Knight II: Jedi Outcast (2002) GCN, Win, Xbox
- Star Wars Jedi Knight: Jedi Academy (2003) Win, Xbox
- Star Wars: Obi-Wan (2002) Xbox
- Star Wars: Republic Commando (2005) Win, Xbox
- Star Wars: The Clone Wars (2002) GCN, PS2, Xbox
- Stealth ATF (1989) NES
- Street Hoops (2002) GCN, PS2, Xbox
- Stuart Little: The Journey Home (2001) GBC
- Supercar Street Challenge (2001) PS2, Win
- Super Pitfall (1987) NES
- Sword Master (1990) NES
Read more about this topic: List Of Activision Games