Leukemia Inhibitory Factor Receptor

Leukemia Inhibitory Factor Receptor

Identifiers Symbols LIFR; CD118; LIF-R; SJS2; STWS; SWS External IDs OMIM: 151443 MGI: 96788 HomoloGene: 1735 GeneCards: LIFR Gene

Gene Ontology
Molecular function	• ciliary neurotrophic factor receptor activity • leukemia inhibitory factor receptor activity • oncostatin-M receptor activity • ciliary neurotrophic factor receptor binding • growth factor binding • cytokine binding
Cellular component	• extracellular region • integral to plasma membrane
Biological process	• cell surface receptor signaling pathway • positive regulation of cell proliferation • cytokine-mediated signaling pathway • organ regeneration • response to cytokine stimulus • oncostatin-M-mediated signaling pathway • neuron projection morphogenesis • leukemia inhibitory factor signaling pathway • ciliary neurotrophic factor-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3977 16880 Ensembl ENSG00000113594 ENSMUSG00000054263 UniProt P42702 P42703 RefSeq (mRNA) NM_001127671.1 NM_001113386.1 RefSeq (protein) NP_001121143.1 NP_001106857.1 Location (UCSC) Chr 5:
38.48 – 38.61 Mb Chr 15:
7.13 – 7.2 Mb PubMed search

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.