Leontine may refer to:
- As a given name
- Leontine Theresa "Lona" Cohen 1913–1992), American spy for the Soviet Union
- Leontine Cooper (1837–1903), Australian trade unionist, suffragist and campaigner for women's rights
- Leontine T. Kelly (born 1910), retired American bishop
- Léontine Lippmann (1844–1910), literary muse and salon hostess
- Léontine de Maësen (1835–1906), Belgian soprano
- Leontien van Moorsel (born 1970), Dutch racing cyclist
- Leontyne Price (born 1927), American soprano
- Leontine Sagan (1889–1974), Austrian actress
- Other uses
- Leontine martyrs, clergy killed in Persia in 455 AD