Leflunomide - Other Potential Indications

Other Potential Indications

Clinical studies regarding the following diseases have been conducted:

  • Polyoma BK Virus Nephropathy
  • Systemic lupus erythematosus
  • Felty's syndrome
  • Takayasu arteritis
  • Wegener's granulomatosis
  • Ankylosing spondylitis
  • Crohn's disease
  • Sarcoidosis
  • Uveitis
  • Still's disease
  • Prostate cancer
  • Pemphigoid.

One study has been made in pediatric patients with juvenile rheumatoid arthritis (JRA). In these, patient group clinical efficacy, side-effect profile, and pharmacokinetic data have been comparable to adult patients with rheumatoid arthritis on Arava alone. The results, however, have been somewhat inferior to the active control group, possibly reflecting a relative underdosing in the lower age of patients group.

Leflunomide has also been utilized for the treatment of Relapsing Polychondritis, but only case reports exist in the literature regarding this usage.

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