Contraindications and Precautions
Leflunomide has a great number of absolute and relative contraindications, in part associated with its mode of action:
- Hypersensitivity to the drug or to inactive ingredients (e.g., lactose).
- Important contraindications are "preexisting pregnancy", or women of childbearing potential not using reliable anticonceptive methods. Women should not become pregnant before 2 years after termination of therapy have elapsed or undergo a rapid wash-out procedure as stated above. Men wishing to father a child should discontinue leflunomide after consultation with their prescribing physician and also undergo the wash-out procedure.
- Preexisting significant liver or renal disease and moderate to severe diseases of the bone marrow or immune system preclude the use of Leflunomide.
- Moderate to severe bacterial, fungal or viral infections (e.g., AIDS, latent HIV-Infection, pneumonia, active tuberculosis).
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