Basic Chemical, Pharmacological, and Marketing Data
Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous.
The substance is sold under the brand name Arava by Sanofi-Aventis. It is available for oral administration as tablets containing 10, 20, or 100 mg of active drug. Arava also contains some inactive ingredients, which could cause allergies or intolerances. Arava was approved by the U.S. Food and Drug Administration (FDA) and in many other countries (e.g., Canada, Europe) in 1998.
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