Science, Mathematics, and Computing
- Laser Camera System, a type of scanner used on the Space Shuttle
- Learning classifier system, machine learning system
- Liquid cooling system (disambiguation), various meanings
- Live Communications Server, Live Communications Server 2005 or Microsoft Office Communications Server, a secure Session Initiation Protocol based instant messaging and VoIP server product
- Locally convex space
- Longest common substring problem in computer science, the longest shared sequence of consecutive characters
- Longest common subsequence problem in computer science, the longest shared sequence of not necessarily consecutive characters
- Liquid Crystal Shutter (3D glasses)
- Local Control System for environmental
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