Athletics
Central Catholic has a long tradition of excellence in the IHSAA and is a member of the Hoosier Athletic Conference. The Knights have had much success, most notably in boy's basketball when the state switched to the class system in 1998, and more recently in baseball where they have been a state finalist six out of the last seven years. In 2010, the Knights football team repeated as state champions to win their 4th class A football state title. As of 2011, no other Indiana Class A school has experienced as much athletic success as Central Catholic. As of 2011, Lafayette Central Catholic has captured 15 state titles (5 in baseball, 5 in football, 3 in boys basketball, 1 in girls basketball and 1 in girls volleyball).
In the early 1980s, Central Catholic became the first high school in Indiana to hire a female to coach a boy's athletic team. Sheila Donahue became the boy’s tennis coach and later received Coach of the Year honors in the conference.
In 2005, Central Catholic hired former Purdue standout Dave Barrett to become the head coach of the boy's basketball program. Barrett, a graduate of Central Catholic, helped lead the Knights to the Lafayette Regional Championship in 1987. While at Purdue, he helped Gene Keady and the Boilermakers capture the 1988 Big Ten Championship.
In 2006, Central Catholic began a football rivalry series with St. Theodore Guerin High School, the only other Catholic High School in the Diocese of Lafayette-in-Indiana. There is a traveling trophy known as the Bishop's Cannon, donated by Bishop William Higi. Bishop Higi was the bishop that oversaw the building and development of St. Guerin. Traditionally, the Bishop will sit for the first half on the side of the team that won the coin toss, then switch at halftime. Central Catholic currently holds a 6-0 lead in the all-time series.
The Central Catholic varsity football team held a winning streak of 48 games, from the beginning of the 2009 season until September 7, 2012 when they were defeated at Culver Military Academy.
Central Catholic Championship Teams
Baseball
- Sectional Champs: 1991, 1998, 2002-2005, 2007, 2009-2012
- Regional Champs: 2002-2005, 2007-2012
- Semi State Champs: 2002-2004, 2007, 2009-2012
- State Champions: 2004, 2007, 2009-2012
Boy's Basketball
- Sectional Champs: 1973, 1987, 1998-2000, 2002-2010
- Regional Champs: 1973, 1987, 1998-2000, 2003, 2007-2009
- Semi State Champs: 1998-2000, 2003
- State Champions: 1998, 2000, 2003
Boy's Cross Country
- Sectional Champs: 1968, 1970, 1976
Football
- Sectional Champs: 1976, 1989, 1999, 2005, 2009-2011
- Regional Champs: 1976, 1999, 2009-2011
- Semi State Champs: 1999, 2009-2011
- State Champions: 1976, 1999, 2009-2011
Girl's Basketball
- Sectional Champs: 2006-2010
- Regional Champs: 2006
- Semi State Champs: 2006
- State Champions: 2006
Girl's Cross Country
- Sectional Champs: 1998
- Regional Champs: 1998
Girl's Golf
- Sectional Champs: 1994
Girl's Softball
- Sectional Champs: 2006
- Regional Champs: 2006
Girl's Swimming
- Conference Champs: 2009, 2010
Girl's Tennis
- Sectional Champs: 2006, 2008
Girl's Volleyball
- Sectional Champs: 2005, 2007-2010
- Regional Champs: 2007, 2008, 2010
- State Champs: 2010
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