Pathophysiology
The pathophysiology of Kimura Disease remains unknown, although an allergic reaction, trauma, and an autoimmune process have all been implicated as the possible cause. The disease is manifested by an abnormal proliferation of lymphoid follicles and vascular endothelium. Peripheral eosinophilia and the presence of eosinophils in the inflammatory infiltrate suggest that Kimura Disease may be a hypersensitivity reaction. Some evidence has indicated that TH2 lymphocytes may also play a role, but further investigation is needed.
Kimura Disease is generally limited to the skin, lymph nodes, and salivary glands, but patients with Kimura Disease and nephrotic syndrome have been reported. The basis of this possible association is unclear.
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