John Zachary Young - Research Work

Research Work

Most of his scientific research was on the nervous system. He discovered the squid giant axon and the corresponding squid giant synapse. His work in the 1930s on signal transmission in, and the fibre structure of, nerves inspired the work of Sir Andrew Huxley and Sir Alan Hodgkin for which they received a Nobel prize.

http://www.youtube.com/watch?v=pw6_Si5jOpo Professor Young demonstrates the squid giant axon

During World War II, responding to the large number of nerve injuries sustained by soldiers in combat and by his pioneering work in comparative anatomy and the regrowth of damaged nerves in squids and octopuses, Young set up a unit at the University of Oxford to study nerve regeneration in mammals. His wartime team, investigating the biochemical conditions which control nerve fibre growth, also sought ways to accelerate the repair of peripheral nerves severed by injury. Working with Peter Medawar, Young found a way to rejoin small peripheral nerves using a "glue" of plasma. This method was eventually modified and used in surgery.

After the war, Young's research interests turned to investigating the central nervous system and the functions of the brain. Continuing to experiment on squids, octopuses and other cephalopods, Young found that they could be trained to respond in specific ways to visual stimuli.

In 1950, Young was invited by the BBC to deliver the Reith Lectures. For his series of eight radio broadcasts, titled Doubt and Certainty in Science, he introduced the BBC audience to the themes of his research, exploring the function of the brain and the then-current scientific methods used to increase understanding of it.

However, he is probably best remembered for his two textbooks, The Life of Vertebrates and The Life of Mammals.

He was President of the Marine Biological Association from 1976 to 1986. His personal research library is held in the National Marine Biological Library at the MBA.

A memorial service was held for him in the Chapel of Magdalen College, Oxford on 9 November 1997.

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