John Palaiologos or Palaeologus may refer to:
- John Palaiologos (Despot), Byzantine general, brother of Byzantine Emperor Michael VIII Palaiologos
- John Palaiologos, Byzantine general, grandson of Byzantine Emperor Michael VIII Palaiologos
- John V Palaiologos, Byzantine emperor, died 1391
- John VII Palaiologos, Byzantine emperor, died 1390
- John VIII Palaiologos, Byzantine emperor, died 1448