Janus Kinase 1

Janus Kinase 1

Identifiers Symbols JAK1; JAK1A; JAK1B; JTK3 External IDs OMIM: 147795 MGI: 96628 HomoloGene: 1678 ChEMBL: 2835 GeneCards: JAK1 Gene EC number 2.7.10.2

Gene Ontology
Molecular function	• protein tyrosine kinase activity • non-membrane spanning protein tyrosine kinase activity • growth hormone receptor binding • protein binding • ATP binding
Cellular component	• nucleus • cytoplasm • cytosol • cytoskeleton • endomembrane system • membrane
Biological process	• protein phosphorylation • enzyme linked receptor protein signaling pathway • intracellular protein kinase cascade • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • intracellular signal transduction • response to antibiotic • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3716 16451 Ensembl ENSG00000162434 ENSMUSG00000028530 UniProt P23458 B1ASP2 RefSeq (mRNA) NM_002227.2 NM_146145.2 RefSeq (protein) NP_002218.2 NP_666257.2 Location (UCSC) Chr 1:
65.3 – 65.43 Mb Chr 4:
101.15 – 101.27 Mb PubMed search

JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.