Isochorismate Synthase

In enzymology, an isochorismate synthase (EC 5.4.4.2) is an enzyme that catalyzes the chemical reaction

chorismate isochorismate

Hence, this enzyme has one substrate, chorismate, and one product, isochorismate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring hydroxy groups. The systematic name of this enzyme class is isochorismate hydroxymutase. This enzyme participates in 2 metabolic pathways: ubiquinone biosynthesis and biosynthesis of siderophore group. In the model plant Arabidopsis thaliana, isochorismate synthase is required for salicylic acid synthesis, which occurs mainly through the chorismate-isochorismate pathway (see Wildermuth 2006 for details).