IRAK2

IRAK2

Identifiers Symbols IRAK2; IRAK-2 External IDs OMIM: 603304 MGI: 2429603 HomoloGene: 1207 GeneCards: IRAK2 Gene

Gene Ontology
Molecular function	• protein kinase activity • protein binding • ATP binding • protein homodimerization activity • protein heterodimerization activity
Cellular component	• cytosol • plasma membrane • cell surface • endosome membrane
Biological process	• activation of MAPK activity • regulation of cytokine-mediated signaling pathway • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • protein phosphorylation • inflammatory response • I-kappaB kinase/NF-kappaB cascade • JNK cascade • Toll signaling pathway • lipopolysaccharide-mediated signaling pathway • negative regulation of NF-kappaB transcription factor activity • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway • innate immune response • positive regulation of NF-kappaB transcription factor activity • stress-activated MAPK cascade • nucleotide-binding oligomerization domain containing signaling pathway • interleukin-1-mediated signaling pathway • response to interleukin-1
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3656 108960 Ensembl ENSG00000134070 ENSMUSG00000060477 UniProt O43187 Q8CFA1 RefSeq (mRNA) NM_001570 NM_001113553 RefSeq (protein) NP_001561 NP_001107025 Location (UCSC) Chr 3:
10.21 – 10.29 Mb Chr 6:
113.64 – 113.7 Mb PubMed search

Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene.

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.