Route Description
Iowa Highway 2 begins at the Nebraska City Bridge just east of Nebraska City, Nebraska. It goes northeast and then east as an expressway until meeting Interstate 29. It then continues east as a two-lane highway until meeting U.S. Highway 275 and turning north. It continues north, bypassing Sidney with U.S. 275, and turning east of Sidney. It goes east and meets U.S. 59 at Shenandoah and then U.S. 71 at Clarinda, which is served with Business Route 2. It continues east through New Market and meets Iowa Highway 148 at Bedford. After intersecting Iowa Highway 25 east of Bedford, it passes through Benton before beginning an overlap with U.S. Highway 169 through Mount Ayr. After passing through Kellerton, Iowa 2 intersects Interstate 35 at Decatur City.
Iowa Highway 2 continues east through Decatur City and meets U.S. Highway 69 in Leon. It continues east and intersects U.S. Highway 65 before entering Corydon, where it intersects Iowa Highway 14. After passing through Promise City, it goes through Centerville, where it intersects Iowa Highway 5. It later intersects Iowa Highway 202 near Moulton and then begins a concurrency with U.S. Highway 63 which ends in Bloomfield.
After Bloomfield, Iowa Highway 2 turns southeasterly to pass through Pulaski, Milton, and Cantril, then turns briefly northeast. It turns east, intersects Iowa Highway 1 south of Keosauqua, then turns southeast towards Farmington. At Farmington, Iowa 2 meets Iowa Highway 81 and crosses the Des Moines River. It continues east and meets U.S. Highway 218 and Iowa Highway 27 at Donnellson. From there, it then meets U.S. Highway 61 and they overlap into Fort Madison. At Fort Madison, the overlap ends and Iowa 2 ends when it crosses the Fort Madison Toll Bridge to enter Illinois.
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