Abbreviation
- iO Theater, a theater in Chicago, Illinois, dedicated to improvisational comedy
- Image orthicon tube, a TV camera used between 1946 and 1968
- Indirect object, the object that is the recipient of an action (by a verb)
- i.o., "in illo ordine", Latin phrase meaning "respectively" ("in that order")
- Industrial organization, the field of economics that studies the strategic behavior of firms, the structure of markets and their interactions
- Industrial and Organizational Psychology, the field of psychology that studies work, academic, and other organizational issues
- Input/output, the collection of interfaces that different functional units of an information processing system use to communicate with each other
- Integrated operations, a term used in the Petroleum Industry describing new work processes and ways of working that have been facilitated by modern information and communication technologies
- International Operations, a fictional American Intelligence Agency in Wildstorm comics
- International Organization, a peer-reviewed journal that covers the entire field of international affairs
- Intraosseous infusion, the medical process of introducing medication directly into the bone marrow
- iO Digital Cable Service, a service offered by Cablevision
- IO Interactive, a Danish computer game developer
- Interest-only, a type of collateralized mortgage obligation (CMO) or mortgage-backed security
- Inventory objective or Insertion order, a business document specifying the inventory goal of an advertising campaign
- Investigating Officer, a police officer in the United Kingdom who heads an investigation, usually from CID but of any rank
- Influx Overdrive
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