Integrative Neuroscience - Motivation

Motivation

Since the ‘decade of the brain’ there has been an explosion of insights into the brain and their application in most areas of medicine. With this explosion, the need for integration of data across studies, modalities and levels of understanding is increasingly recognized. A concrete exemplar of the value of large-scale data sharing has been provided by the Human Brain Project.

The importance of large-scale integration of brain information for new approaches to medicine has been recognized. Rather than relying mainly on symptom information, a combination of brain and gene information may ultimately be required for understanding what treatment is best suited to which individual person.

It provides a framework for linking the great diversity of specializations within contemporary neuroscience, including

• Molecular neuroscience — genetic and cellular aspects of brain function
• Neuroanatomy — connections, networks, neurotransmitter systems
• Behavioral neuroscience — the overt consequences of neural activity
• Systems neuroscience — description of sensory and motors systems
• Developmental neuroscience — structural and functional changes during maturation
• Cognitive neuroscience — channels and stages of sensory processing, including memory
• Mathematical neuroscience — quantitative simulation and emulation of neuronal and brain function
• Clinical observations — evidence that can be gleaned from brain dysfunction

This diversity is inevitable, yet has arguably created a void: neglect of the primary role of the nervous system in enabling the animal to survive and prosper. Integrative neuroscience aims to fill this perceived void.