Insulin Aspart - Variations On Insulin Aspart

Variations On Insulin Aspart

NovoLog Mix 70/30 is a product marketed by Novo Nordisk which contains 30% insulin aspart and 70% insulin aspart protamine. The insulin aspart protamine portion is a crystalline form of insulin aspart, which delays the action of the insulin, giving it a prolonged absorption profile after injection. The combination of the fast-acting form and the long-acting form allows the patient to receive fewer injections over the course of the day.

The components of NovoLog Mix 70/30 are as follows:

• Metal ion – zinc (19.6 ug/mL)
• Buffer – dibasic sodium phosphate (1.25 mg/mL)
• Preservative – m-cresol (1.72 mg/mL) and phenol (1.50 mg/mL)
• Isotonicity agent – sodium chloride (0.58 mg/mL) and mannitol (36.4 mg/mL)
• Modifying protein – protamine (0.33 mg/mL)

The pH is 7.2-7.44.

NovoLog Mix is marketed to be used with the Novo Nordisk FlexPen. The onset of action is less than 30 minutes, the peak action is reached in 1–4 hours, and the duration is less than 24 hours.

NovoLog® is available in different forms. There are 10-mL vials, 3-mL PenFill® cartridges, and 3mL NovoLog® FlexPens®. The NovoLog® FlexPen® is a way to take NovoLog® via a prefilled, disposable insulin pen delivery system. The NovoLog® FlexPen® can be used for up to 28 days without being refrigerated once it has been used. The large, clear dosing window allows for accurate dose setting and adjustment. NovoLog® is also supplied in 3-mL PenFill® cartridges and can be used in the NovoPen® 3 insulin delivery system.