Shifted Isoelectric Point Insulins
Normal unmodified insulin is soluble at physiological pH. Analogues have been created that have a shifted isoelectric point so that they exist in a solubility equilibrium in which most precipitates out but slowly dissolves in the bloodstream and is eventually excreted by the kidneys. These insulin analogues are used to replace the basal level of insulin, and may be effective over a period of up to 24 hours. However, some insulin analogues, such as insulin detemir, bind to albumin rather than fat like earlier insulin varieties, and results from long-term usage (e.g. more than 10 years) have never been released.
Read more about this topic: Insulin Analog
Famous quotes containing the words shifted and/or point:
“The “female culture” has shifted more rapidly than the “male culture”; the image of the go-get ‘em woman has yet to be fully matched by the image of the let’s take-care-of-the-kids- together man. More important, over the last thirty years, men’s underlying feelings about taking responsibility at home have changed much less than women’s feelings have changed about forging some kind of identity at work.”
—Arlie Hochschild (20th century)
“From a purely external point of view there is no will; and to find will in any phenomenon requires a certain empathy; we observe a man’s actions and place ourselves partly but not wholly in his position; or we act, and place ourselves partly in the position of an outsider.”
—T.S. (Thomas Stearns)