Insulin-like Growth Factor 1 Receptor
| Gene Ontology | |
|---|---|
| Molecular function | • protein tyrosine kinase activity • insulin-like growth factor-activated receptor activity • insulin receptor binding • protein binding • insulin-like growth factor binding • ATP binding • insulin-like growth factor I binding • identical protein binding • phosphatidylinositol 3-kinase binding • insulin binding • insulin receptor substrate binding |
| Cellular component | • integral to plasma membrane • caveola • membrane • neuron projection • intracellular membrane-bounded organelle |
| Biological process | • immune response • signal transduction • axonogenesis • brain development • positive regulation of cell proliferation • insulin receptor signaling pathway • phosphatidylinositol 3-kinase cascade • establishment of cell polarity • male sex determination • positive regulation of cell migration • mammary gland development • exocrine pancreas development • positive regulation of cytokinesis • response to vitamin E • negative regulation of apoptotic process • positive regulation of MAPK cascade • positive regulation of DNA replication • regulation of JNK cascade • protein autophosphorylation • insulin-like growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • protein tetramerization • protein heterooligomerization • inactivation of MAPKK activity • positive regulation of protein kinase B signaling cascade • negative regulation of protein kinase B signaling cascade • prostate gland epithelium morphogenesis • positive regulation of steroid hormone biosynthetic process |
| Sources: Amigo / QuickGO | |
99.19 – 99.51 Mb
67.95 – 68.23 Mb
The Insulin-like Growth Factor 1 (IGF-1) Receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass.
Read more about Insulin-like Growth Factor 1 Receptor: Structure, Family Members, Inhibitors, Interactions, Regulation
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