Insulin-like Growth Factor 1 Receptor

Insulin-like Growth Factor 1 Receptor

Identifiers Symbols IGF1R; CD221; IGFIR; IGFR; JTK13 External IDs OMIM: 147370 MGI: 96433 HomoloGene: 30997 ChEMBL: 1957 GeneCards: IGF1R Gene EC number 2.7.10.1

Gene Ontology
Molecular function	• protein tyrosine kinase activity • insulin-like growth factor-activated receptor activity • insulin receptor binding • protein binding • insulin-like growth factor binding • ATP binding • insulin-like growth factor I binding • identical protein binding • phosphatidylinositol 3-kinase binding • insulin binding • insulin receptor substrate binding
Cellular component	• integral to plasma membrane • caveola • membrane • neuron projection • intracellular membrane-bounded organelle
Biological process	• immune response • signal transduction • axonogenesis • brain development • positive regulation of cell proliferation • insulin receptor signaling pathway • phosphatidylinositol 3-kinase cascade • establishment of cell polarity • male sex determination • positive regulation of cell migration • mammary gland development • exocrine pancreas development • positive regulation of cytokinesis • response to vitamin E • negative regulation of apoptotic process • positive regulation of MAPK cascade • positive regulation of DNA replication • regulation of JNK cascade • protein autophosphorylation • insulin-like growth factor receptor signaling pathway • phosphatidylinositol-mediated signaling • protein tetramerization • protein heterooligomerization • inactivation of MAPKK activity • positive regulation of protein kinase B signaling cascade • negative regulation of protein kinase B signaling cascade • prostate gland epithelium morphogenesis • positive regulation of steroid hormone biosynthetic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3480 16001 Ensembl ENSG00000140443 ENSMUSG00000005533 UniProt P08069 Q60751 RefSeq (mRNA) NM_000875.3 NM_010513.2 RefSeq (protein) NP_000866.1 NP_034643.2 Location (UCSC) Chr 15:
99.19 – 99.51 Mb Chr 7:
67.95 – 68.23 Mb PubMed search

The Insulin-like Growth Factor 1 (IGF-1) Receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called Insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass.