Organs and Tissues Affected By IGF-1
Since many distinct tissue types express the IGF-1 receptor, IGF-1's effects are diverse. It acts as a neurotrophic factor, inducing the survival of neurons. It causes skeletal muscle hypertrophy, by inducing protein synthesis, and by blocking muscle atrophy. It is protective for cartilage cells, and is associated with activation of osteocytes, and thus may be an anabolic factor for bone. Since at high concentrations it is capable of activating the insulin receptor, it can also complement for the effects of insulin.
Read more about this topic: Insulin-like Growth Factor
Famous quotes containing the words organs and/or affected:
“But the man and woman of seventy assume to know all, they have outlived their hope, they renounce aspiration, accept the actual for the necessary and talk down to the young. Let them then become organs of the Holy Ghost; let them be lovers; let them behold truth; and their eyes are uplifted, their wrinkles smoothed, they are perfumed again with hope and power.”
—Ralph Waldo Emerson (18031882)
“My first reading of Tolstoy affected me as a revelation from heaven, as the trumpet of the judgment. What he made me feel was not the desire to imitate, but the conviction that imitation was futile.”
—Ellen Glasgow (18731945)