ID3 (gene)

ID3 (gene)

Identifiers Symbols ID3; HEIR-1; bHLHb25 External IDs OMIM: 600277 MGI: 96398 HomoloGene: 1633 GeneCards: ID3 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • transcription corepressor activity • transcription factor binding • protein domain specific binding • protein dimerization activity
Cellular component	• nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • metanephros development • regulation of DNA replication • transcription, DNA-dependent • multicellular organismal development • central nervous system development • heart development • response to wounding • neuron differentiation • epithelial cell differentiation • notochord development • odontogenesis • positive regulation of apoptotic process • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of osteoblast differentiation • negative regulation of transcription, DNA-dependent • regulation of cell cycle
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3399 15903 Ensembl ENSG00000117318 ENSMUSG00000007872 UniProt Q02535 P41133 RefSeq (mRNA) NM_002167 NM_008321 RefSeq (protein) NP_002158 NP_032347 Location (UCSC) Chr 1:
23.88 – 23.89 Mb Chr 4:
136.14 – 136.15 Mb PubMed search

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.