Hypoxia-inducible Factors - Structure

Structure

Most, if not all, oxygen-breathing species express the highly-conserved transcriptional complex HIF-1, which is a heterodimer composed of an alpha and a beta subunit, the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1 belongs to the PER-ARNT-SIM (PAS) subfamily of the basic helix-loop-helix (bHLH) family of transcription factors. The alpha and beta subunit are similar in structure and both contain the following domains:

  • N-terminus – a bHLH domain for DNA binding
  • central region – Per-ARNT-Sim (PAS) domain which facilitates heterodimerization
  • C-terminus – recruits transcriptional coregulatory proteins
Hypoxia-inducible factor-1
Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex.
Identifiers
Symbol HIF-1
Pfam PF11413
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary
HIF-1 alpha C terminal transactivation domain
Structure of hypoxia inducible factor-1 alpha subunit.
Identifiers
Symbol HIF-1a_CTAD
Pfam PF08778
InterPro IPR014887
SCOP 1l3e
SUPERFAMILY 1l3e
Available protein structures:
Pfam structures
PDB RCSB PDB; PDBe
PDBsum structure summary

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