Hypersensitivity - Coombs and Gell Classification

Coombs and Gell Classification

Comparison of hypersensitivity types
Type Alternative names Often mentioned disorders Mediators
I Allergy (immediate)
  • Atopy
  • Anaphylaxis
  • Asthma
  • IgE and IgG4
II Cytotoxic, antibody-dependent
  • Autoimmune hemolytic anemia
  • Thrombocytopenia
  • Erythroblastosis fetalis
  • Goodpasture's syndrome
  • Membranous nephropathy
  • Graves' disease *see type V explanation below
  • Myasthenia Gravis *see type V explanation below
  • IgM or IgG
  • (Complement)
III Immune complex disease
  • Serum sickness
  • Arthus reaction
  • Rheumatoid arthritis
  • Post streptococcal glomerulonephritis
  • lupus Nephritis
  • Systemic lupus erythematosus (SLE)
  • Extrinsic allergic alveolitis (Hypersensitivity pneumonitis)
  • IgG
  • (Complement)
IV Delayed-type hypersensitivity (DTH), cell-mediated immune memory response, antibody-independent
  • Contact dermatitis
  • Mantoux test
  • Chronic transplant rejection
  • Multiple sclerosis
  • T-cells
V Autoimmune disease, receptor mediated (see below)
  • Graves' disease
  • Myasthenia Gravis
  • IgM or IgG
  • (Complement)

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