Coombs and Gell Classification
Comparison of hypersensitivity types
Type |
Alternative names |
Often mentioned disorders |
Mediators |
I |
Allergy (immediate) |
|
|
II |
Cytotoxic, antibody-dependent |
- Autoimmune hemolytic anemia
- Thrombocytopenia
- Erythroblastosis fetalis
- Goodpasture's syndrome
- Membranous nephropathy
- Graves' disease *see type V explanation below
- Myasthenia Gravis *see type V explanation below
|
|
III |
Immune complex disease |
- Serum sickness
- Arthus reaction
- Rheumatoid arthritis
- Post streptococcal glomerulonephritis
- lupus Nephritis
- Systemic lupus erythematosus (SLE)
- Extrinsic allergic alveolitis (Hypersensitivity pneumonitis)
|
|
IV |
Delayed-type hypersensitivity (DTH), cell-mediated immune memory response, antibody-independent |
- Contact dermatitis
- Mantoux test
- Chronic transplant rejection
- Multiple sclerosis
|
|
V |
Autoimmune disease, receptor mediated (see below) |
- Graves' disease
- Myasthenia Gravis
|
|