Surname
- Karim al-Hussayni, Imam of the Ismaili Muslims, descendant of the Prophet Muhammad and the fourth Aga Khan.
- Roquia Sakhawat Hussain, Famous Bangladeshi Social Worker and a Muslim Feminist
- Abrar Hussain, Pakistani military hero
- Abrar Hussain, Pakistani boxer
- Rizwan Hussain, British Barrister of Bangladeshi Descent
- Ali bin Hussein of Hejaz, King of Hejaz and Grand Sharif of Mecca
- Fouad Hussein, Jordanian journalist
- Hasib Hussain, English bomber in the 7/7 attacks
- Hussein el-Husseini, former speaker of the Lebanese parliament
- M.F. Husain, Indian artist
- Metin Hüseyin, English film director
- Muhammad Husayn Haykal, Egyptian writer, journalist, and politician
- Nasser Hussain, former Essex and England cricketer
- Robert Hossein, French actor, director and writer
- Rashad Hussain, United States special envoy to the Organization of the Islamic Conference
- Sharif Ali bin al-Hussein, pretender to the throne of Iraq
- Taha Hussein, Egyptian writer and Arabic literary scholar
- Tahir ibn Husayn, Persian general and governor during the Abbasid caliphate
- Zakir Hussain, Indian tabla player
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