E
- Eddie Hughes (born 1960), American basketball player
- Edward Hughes, Catholic priest and exorcist
- Edward Hughes Ball Hughes (1798-1863), English dandy
- Edwin Holt Hughes (1866–1950), Bishop of the Methodist Episcopal Church
- Emily Hughes (born 1989), American figure skater
- Emlyn Hughes (1947–2004), Liverpool F.C. and England national football team captain
Read more about this topic: Hughes (surname)