A
- Aaron Hughes, footballer
- Adam Hughes, American comic book illustrator
- Adam Hughes (footballer) (born 1982), Australian association footballer
- Adam Hughes (rugby) (born 1977), English born Welsh rugby league and rugby league player
- Adam Hughes (rugby union) (born 1990), Welsh rugby union player
- Adam Munson, also known as Adam Hughes, fictional character
- Alex Hughes, cartoonist
- Alex Hughes (cricketer) (born 1991), English cricketer
- Alexander Minto Hughes, English ska and reggae musician (1945–1998)
- Andrew Hughes (disambiguation), several people
- Andy Hughes, electronic music producer
- Anthony Hughes (born 1948), English judge
- Arthur Hughes (artist) (1831–1915), English painter
- Arthur Hughes (actor) (1894–1982), American actor and radio personality
- Arwel Hughes, Welsh composer and conductor
- Augusto Hughes (1931–1993), Argentine Air Force commander and Junta member
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