HSD17B8

Identifiers Symbols HSD17B8; D6S2245E; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1; dJ1033B10.9 External IDs OMIM: 601417 MGI: 95911 HomoloGene: 56588 GeneCards: HSD17B8 Gene EC number 1.1.1.63 1.1.1.62, 1.1.1.63

Gene Ontology
Molecular function	• nucleotide binding • 3-hydroxyacyl-CoA dehydrogenase activity • estradiol 17-beta-dehydrogenase activity • protein binding • testosterone dehydrogenase (NAD+) activity • testosterone 17-beta-dehydrogenase (NAD+) activity
Cellular component	• mitochondrial envelope • mitochondrial matrix • plasma membrane
Biological process	• fatty acid biosynthetic process • estrogen biosynthetic process • androgen metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7923 14979 Ensembl ENSG00000112474 ENSMUSG00000073422 UniProt Q92506 P50171 RefSeq (mRNA) NM_014234 NM_013543 RefSeq (protein) NP_055049 NP_038571 Location (UCSC) Chr 6:
33.17 – 33.17 Mb Chr 17:
34.03 – 34.03 Mb PubMed search

Estradiol 17-beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.