HSD17B10

HSD17B10

Identifiers Symbols HSD17B10; 17b-HSD10; ABAD; CAMR; DUPXp11.22; ERAB; HADH2; HCD2; MHBD; MRPP2; MRX17; MRX31; MRXS10; SCHAD; SDR5C1 External IDs OMIM: 300256 MGI: 1333871 HomoloGene: 68403 ChEMBL: 4159 GeneCards: HSD17B10 Gene EC number 1.1.1.35 1.1.1.178, 1.1.1.35

Gene Ontology
Molecular function	• beta-amyloid binding • 3-hydroxyacyl-CoA dehydrogenase activity • estradiol 17-beta-dehydrogenase activity • steroid binding • protein binding • cholate 7-alpha-dehydrogenase activity • acetoacetyl-CoA reductase activity • estrogen receptor binding • identical protein binding • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity • NAD binding
Cellular component	• cytoplasm • mitochondrion • mitochondrial inner membrane • mitochondrial matrix • endoplasmic reticulum • plasma membrane
Biological process	• lipid metabolic process • cell aging • tRNA processing • branched-chain amino acid catabolic process • Leydig cell differentiation • cellular nitrogen compound metabolic process • small molecule metabolic process • protein homotetramerization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3028 15108 Ensembl ENSG00000072506 ENSMUSG00000025260 UniProt Q99714 A2AFQ2 RefSeq (mRNA) NM_001037811 NM_016763 RefSeq (protein) NP_001032900 NP_058043 Location (UCSC) Chr HG1433_PATCH:
53.17 – 53.18 Mb Chr X:
152 – 152 Mb PubMed search

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by the HSD17B10 (hydroxysteroid (17β) dehydrogenase 10) gene. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.