HRU or Hru may refer to:
- HRU (security), the Harrison, Ruzzo and Ullman security model
- Hru, a minor Enochian angel
- Herington Regional Airport, IATA code HRU
- "How are you?", in Internet chat shorthand
- Hruso languages, ISO 639-3 code hru
- Human Readable URL, a popular technology used in websites (mostly CMS) for:
- better indexing of a site's contents, especially for Google & Yandex search engines;
- more easily remembered page URLs, replacing numeric page addresses
- North Harbour Rugby Union, New Zealand rugby team known as Harbour Rugby Union or HRU
- HRU also stand for High Representative of the Union- the EU's External relations official