HOXD9

Identifiers Symbols HOXD9; HOX4; HOX4C; Hox-4.3; Hox-5.2 External IDs OMIM: 142982 MGI: 96210 HomoloGene: 8409 GeneCards: HOXD9 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• transcription, DNA-dependent • skeletal muscle tissue development • adult locomotory behavior • anterior/posterior pattern specification • proximal/distal pattern formation • mammary gland development • embryonic forelimb morphogenesis • hindlimb morphogenesis • positive regulation of transcription from RNA polymerase II promoter • embryonic skeletal system morphogenesis • peripheral nervous system neuron development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3235 15438 Ensembl ENSG00000128709 ENSMUSG00000043342 UniProt P28356 P28357 RefSeq (mRNA) NM_014213 NM_013555 RefSeq (protein) NP_055028 NP_038583 Location (UCSC) Chr 2:
176.99 – 176.99 Mb Chr 2:
74.7 – 74.7 Mb PubMed search

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.