HOXB7

Identifiers Symbols HOXB7; HHO.C1; HOX2; HOX2C; Hox-2.3 External IDs OMIM: 142962 MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • protein binding • sequence-specific DNA binding
Cellular component	• nucleus • nucleolus • cytoplasm
Biological process	• transcription, DNA-dependent • regulation of transcription, DNA-dependent • multicellular organismal development • anterior/posterior pattern specification • myeloid cell differentiation • embryonic skeletal system morphogenesis • positive regulation of branching involved in ureteric bud morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 3217 15415 Ensembl ENSG00000120087 ENSMUSG00000038721 UniProt P09629 P09024 RefSeq (mRNA) NM_004502 NM_010460 RefSeq (protein) NP_004493 NP_034590 Location (UCSC) Chr 17:
46.68 – 46.69 Mb Chr 11:
96.28 – 96.29 Mb PubMed search

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.